Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
نویسندگان
چکیده
منابع مشابه
Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling
OBJECTIVE To test whether Toll-like receptor (TLR) signaling plays a key role for reduced nuclear factor B (NF-κB) activation after laquinimod treatment in the model of cuprizone-induced demyelination, oligodendrocyte apoptosis, inflammation, and axonal damage. METHODS Ten-week-old C57BL/6J, TLR4(-/-), and MyD88(-/-) mice received 0.25% cuprizone for 6 weeks and were treated daily with 25 mg/...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2012
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-012-1009-1